\n\u6c34\u6eb6\u6027<\/td>\n | \u6613\u6eb6\u4e8e\u6c34<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \u4ece\u4e0a\u8868\u53ef\u4ee5\u770b\u51fa\uff0c1-\u7532\u57fa\u54aa\u5511\u662f\u4e00\u79cd\u4f4e\u7194\u70b9\u3001\u9ad8\u6cb8\u70b9\u7684\u6db2\u4f53\uff0c\u4e14\u6613\u6eb6\u4e8e\u6c34\u548c\u5176\u4ed6\u6781\u6027\u6eb6\u5242\u3002\u8fd9\u79cd\u6eb6\u89e3\u6027\u4f7f\u5b83\u6210\u4e3a\u8bb8\u591a\u5316\u5b66\u53cd\u5e94\u7684\u7406\u60f3\u50ac\u5316\u5242\u6216\u6eb6\u5242\u3002<\/p>\n \nNMI\u7684\u5236\u5907\u65b9\u6cd5<\/h2>\n1-\u7532\u57fa\u54aa\u5511\u7684\u5408\u6210\u65b9\u6cd5\u591a\u79cd\u591a\u6837\uff0c\u5176\u4e2d\u5e38\u89c1\u7684\u662f\u901a\u8fc7\u54aa\u5511\u4e0e\u7898\u7532\u70f7\uff08CH3I\uff09\u7684\u7532\u57fa\u5316\u53cd\u5e94\u6765\u5236\u5907\uff1a<\/p>\n Imidazole + CH3I \u2192 1-Methylimidazole + HI<\/code><\/pre>\n\u6b64\u5916\uff0c\u8fd8\u53ef\u4ee5\u901a\u8fc7\u5176\u4ed6\u9014\u5f84\u5408\u6210NMI\uff0c\u4f8b\u5982\u4f7f\u7528\u4e8c\u7532\u57fa\u4e9a\u781c\uff08DMSO\uff09\u4f5c\u4e3a\u53cd\u5e94\u4ecb\u8d28\uff0c\u6216\u8005\u5229\u7528\u7eff\u8272\u5316\u5b66\u65b9\u6cd5\u51cf\u5c11\u526f\u4ea7\u7269\u7684\u751f\u6210\u3002<\/p>\n \u5236\u5907\u65b9\u6cd5\u5bf9\u6bd4<\/h3>\n\n\n\n\u65b9\u6cd5<\/strong><\/th>\n\u4f18\u70b9<\/strong><\/th>\n\u7f3a\u70b9<\/strong><\/th>\n<\/tr>\n<\/thead>\n\n\n\u54aa\u5511\u4e0e\u7898\u7532\u70f7\u53cd\u5e94<\/td>\n | \u53cd\u5e94\u6761\u4ef6\u6e29\u548c\uff0c\u4ea7\u7387\u8f83\u9ad8<\/td>\n | \u9700\u8981\u5904\u7406\u8150\u8680\u6027\u7684HI<\/td>\n<\/tr>\n | \n\u4f7f\u7528DMSO\u4f5c\u4e3a\u4ecb\u8d28<\/td>\n | \u51cf\u5c11\u526f\u53cd\u5e94\uff0c\u73af\u4fdd<\/td>\n | \u6210\u672c\u8f83\u9ad8<\/td>\n<\/tr>\n | \n\u5fae\u6ce2\u8f85\u52a9\u5408\u6210<\/td>\n | \u53cd\u5e94\u65f6\u95f4\u77ed<\/td>\n | \u8bbe\u5907\u8981\u6c42\u9ad8<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \u4e0d\u540c\u7684\u5236\u5907\u65b9\u6cd5\u5404\u6709\u5343\u79cb\uff0c\u5177\u4f53\u9009\u62e9\u53d6\u51b3\u4e8e\u5b9e\u9645\u9700\u6c42\u548c\u7ecf\u6d4e\u6761\u4ef6\u3002<\/p>\n \nNMI\u7684\u7269\u7406\u5316\u5b66\u6027\u8d28<\/h2>\n1-\u7532\u57fa\u54aa\u5511\u7684\u7269\u7406\u5316\u5b66\u6027\u8d28\u51b3\u5b9a\u4e86\u5b83\u5728\u5404\u79cd\u5e94\u7528\u573a\u666f\u4e2d\u7684\u8868\u73b0\u3002\u4e0b\u9762\u6211\u4eec\u8be6\u7ec6\u63a2\u8ba8\u5b83\u7684\u51e0\u4e2a\u5173\u952e\u7279\u6027\u3002<\/p>\n 1. \u9ad8\u78b1\u6027<\/h3>\nNMI\u5177\u6709\u8f83\u5f3a\u7684\u78b1\u6027\uff0c\u8fd9\u662f\u7531\u4e8e\u54aa\u5511\u73af\u4e0a\u7684\u6c2e\u539f\u5b50\u80fd\u591f\u63a5\u53d7\u8d28\u5b50\uff08H\u207a\uff09\u3002\u8fd9\u79cd\u78b1\u6027\u4f7f\u5176\u6210\u4e3a\u8bb8\u591a\u9178\u50ac\u5316\u53cd\u5e94\u7684\u7406\u60f3\u6291\u5236\u5242\u6216\u8c03\u8282\u5242\u3002<\/p>\n 2. \u826f\u597d\u7684\u914d\u4f4d\u80fd\u529b<\/h3>\nNMI\u4e2d\u7684\u4e24\u4e2a\u6c2e\u539f\u5b50\u53ef\u4ee5\u4e0e\u91d1\u5c5e\u79bb\u5b50\u5f62\u6210\u7a33\u5b9a\u7684\u914d\u5408\u7269\uff0c\u8fd9\u4e00\u7279\u6027\u5728\u91d1\u5c5e\u8403\u53d6\u3001\u5206\u79bb\u4ee5\u53ca\u50ac\u5316\u9886\u57df\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002<\/p>\n 3. \u7a33\u5b9a\u6027<\/h3>\n\u5c3d\u7ba1NMI\u5728\u9ad8\u6e29\u4e0b\u53ef\u80fd\u4f1a\u53d1\u751f\u5206\u89e3\uff0c\u4f46\u5b83\u5728\u5e38\u6e29\u4e0b\u7684\u7a33\u5b9a\u6027\u975e\u5e38\u51fa\u8272\u3002\u8fd9\u4f7f\u5f97\u5b83\u80fd\u591f\u5728\u957f\u65f6\u95f4\u50a8\u5b58\u548c\u8fd0\u8f93\u8fc7\u7a0b\u4e2d\u4fdd\u6301\u6027\u80fd\u4e0d\u53d8\u3002<\/p>\n \nNMI\u7684\u5e94\u7528\u9886\u57df<\/h2>\n1-\u7532\u57fa\u54aa\u5511\u56e0\u5176\u72ec\u7279\u7684\u5316\u5b66\u6027\u8d28\uff0c\u5728\u591a\u4e2a\u9886\u57df\u4e2d\u5f97\u5230\u4e86\u5e7f\u6cdb\u5e94\u7528\u3002\u4ee5\u4e0b\u662f\u4e00\u4e9b\u5178\u578b\u7684\u5e94\u7528\u6848\u4f8b\u3002<\/p>\n 1. \u50ac\u5316\u5242<\/h3>\nNMI\u662f\u4e00\u79cd\u9ad8\u6548\u7684\u50ac\u5316\u5242\uff0c\u5e7f\u6cdb\u7528\u4e8e\u805a\u5408\u53cd\u5e94\u3001\u916f\u5316\u53cd\u5e94\u548c\u52a0\u6210\u53cd\u5e94\u7b49\u3002\u4f8b\u5982\uff0c\u5728\u73af\u6c27\u6811\u8102\u7684\u56fa\u5316\u8fc7\u7a0b\u4e2d\uff0cNMI\u53ef\u4ee5\u663e\u8457\u63d0\u9ad8\u53cd\u5e94\u901f\u7387\u5e76\u6539\u5584\u7ec8\u4ea7\u54c1\u7684\u6027\u80fd\u3002<\/p>\n \n\n\n\u5e94\u7528<\/strong><\/th>\n\u4f5c\u7528<\/strong><\/th>\n<\/tr>\n<\/thead>\n\n\n\u73af\u6c27\u6811\u8102\u56fa\u5316<\/td>\n | \u63d0\u9ad8\u56fa\u5316\u901f\u5ea6\uff0c\u589e\u5f3a\u673a\u68b0\u6027\u80fd<\/td>\n<\/tr>\n | \n\u916f\u5316\u53cd\u5e94<\/td>\n | \u52a0\u901f\u53cd\u5e94\u8fdb\u7a0b\uff0c\u51cf\u5c11\u526f\u4ea7\u7269\u751f\u6210<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n2. \u91d1\u5c5e\u87af\u5408\u5242<\/h3>\n\u7531\u4e8eNMI\u5177\u6709\u826f\u597d\u7684\u914d\u4f4d\u80fd\u529b\uff0c\u5b83\u53ef\u4ee5\u4e0e\u591a\u79cd\u91d1\u5c5e\u79bb\u5b50\u5f62\u6210\u7a33\u5b9a\u7684\u87af\u5408\u7269\u3002\u8fd9\u4e00\u7279\u6027\u5728\u91d1\u5c5e\u63d0\u53d6\u3001\u5e9f\u6c34\u5904\u7406\u548c\u5206\u6790\u5316\u5b66\u4e2d\u5c24\u4e3a\u91cd\u8981\u3002<\/p>\n 3. \u519c\u836f\u4e2d\u95f4\u4f53<\/h3>\nNMI\u662f\u67d0\u4e9b\u519c\u836f\u7684\u91cd\u8981\u4e2d\u95f4\u4f53\uff0c\u4f8b\u5982\u7528\u4e8e\u5408\u6210\u6740\u83cc\u5242\u548c\u6740\u866b\u5242\u3002\u901a\u8fc7\u5f15\u5165\u7279\u5b9a\u7684\u529f\u80fd\u57fa\u56e2\uff0cNMI\u53ef\u4ee5\u8f6c\u5316\u4e3a\u9ad8\u6548\u7684\u519c\u4e1a\u5316\u5b66\u54c1\u3002<\/p>\n 4. \u751f\u7269\u533b\u5b66\u9886\u57df<\/h3>\n\u8fd1\u5e74\u6765\uff0cNMI\u5728\u751f\u7269\u533b\u5b66\u9886\u57df\u7684\u5e94\u7528\u9010\u6e10\u589e\u591a\u3002\u7814\u7a76\u8868\u660e\uff0cNMI\u53ef\u4ee5\u4f5c\u4e3a\u836f\u7269\u8f7d\u4f53\u6216\u6d3b\u6027\u6210\u5206\uff0c\u7528\u4e8e\u6cbb\u7597\u67d0\u4e9b\u75be\u75c5\u3002\u4f8b\u5982\uff0c\u57fa\u4e8eNMI\u7684\u5316\u5408\u7269\u5df2\u88ab\u5f00\u53d1\u7528\u4e8e\u6297\u80bf\u7624\u548c\u6297\u83cc\u6cbb\u7597\u3002<\/p>\n \n\u56fd\u5185\u5916\u7814\u7a76\u8fdb\u5c55<\/h2>\n\u5173\u4e8e1-\u7532\u57fa\u54aa\u5511\u7684\u7814\u7a76\uff0c\u56fd\u5185\u5916\u5b66\u8005\u90fd\u6295\u5165\u4e86\u5927\u91cf\u7cbe\u529b\u3002\u4ee5\u4e0b\u662f\u4e00\u4e9b\u503c\u5f97\u5173\u6ce8\u7684\u7814\u7a76\u6210\u679c\u3002<\/p>\n \u56fd\u5185\u7814\u7a76<\/h3>\n\u4e2d\u56fd\u79d1\u5b66\u9662\u67d0\u7814\u7a76\u6240\u7684\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0cNMI\u53ef\u4ee5\u901a\u8fc7\u8c03\u63a7\u5176\u8868\u9762\u4fee\u9970\uff0c\u663e\u8457\u63d0\u9ad8\u5176\u5728\u91d1\u5c5e\u79bb\u5b50\u5206\u79bb\u4e2d\u7684\u6548\u7387\u3002\u8be5\u7814\u7a76\u4e3a\u5de5\u4e1a\u5e9f\u6c34\u5904\u7406\u63d0\u4f9b\u4e86\u65b0\u7684\u601d\u8def\u3002<\/p>\n \u56fd\u5916\u7814\u7a76<\/h3>\n\u7f8e\u56fd\u9ebb\u7701\u7406\u5de5\u5b66\u9662\uff08MIT\uff09\u7684\u4e00\u4e2a\u56e2\u961f\u53d1\u73b0\uff0cNMI\u5728\u7eb3\u7c73\u6750\u6599\u5408\u6210\u4e2d\u5177\u6709\u72ec\u7279\u4f18\u52bf\u3002\u4ed6\u4eec\u5229\u7528NMI\u6210\u529f\u5236\u5907\u4e86\u4e00\u79cd\u65b0\u578b\u7684\u5bfc\u7535\u805a\u5408\u7269\uff0c\u8be5\u6750\u6599\u5728\u67d4\u6027\u7535\u5b50\u5668\u4ef6\u4e2d\u8868\u73b0\u51fa\u8272\u3002<\/p>\n \n\n\n\u7814\u7a76\u673a\u6784<\/strong><\/th>\n\u4e3b\u8981\u6210\u679c<\/strong><\/th>\n<\/tr>\n<\/thead>\n\n\n\u4e2d\u56fd\u79d1\u5b66\u9662<\/td>\n | \u63d0\u9ad8\u91d1\u5c5e\u79bb\u5b50\u5206\u79bb\u6548\u7387<\/td>\n<\/tr>\n | \n\u9ebb\u7701\u7406\u5de5\u5b66\u9662\uff08MIT\uff09<\/td>\n | \u5f00\u53d1\u65b0\u578b\u5bfc\u7535\u805a\u5408\u7269<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \n\u5b89\u5168\u6027\u548c\u73af\u5883\u5f71\u54cd<\/h2>\n\u5c3d\u7ba11-\u7532\u57fa\u54aa\u5511\u5177\u6709\u8bf8\u591a\u4f18\u70b9\uff0c\u4f46\u5728\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u4ecd\u9700\u6ce8\u610f\u5176\u5b89\u5168\u6027\u548c\u5bf9\u73af\u5883\u7684\u5f71\u54cd\u3002<\/p>\n \u6bd2\u7406\u5b66\u6570\u636e<\/h3>\n\u6839\u636e\u73b0\u6709\u7814\u7a76\uff0cNMI\u5bf9\u4eba\u7c7b\u548c\u52a8\u7269\u7684\u6bd2\u6027\u8f83\u4f4e\uff0c\u4f46\u4ecd\u9700\u907f\u514d\u957f\u671f\u63a5\u89e6\u6216\u5438\u5165\u3002\u4ee5\u4e0b\u662f\u5176\u6bd2\u7406\u5b66\u53c2\u6570\uff1a<\/p>\n \n\n\n\u6307\u6807<\/strong><\/th>\n\u503c<\/strong><\/th>\n<\/tr>\n<\/thead>\n\n\nLD50\uff08\u5c0f\u9f20\u53e3\u670d\uff09<\/td>\n | >5000 mg\/kg<\/td>\n<\/tr>\n | \n\u76ae\u80a4\u523a\u6fc0\u6027<\/td>\n | \u8f7b\u5fae\u523a\u6fc0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\u73af\u5883\u4fdd\u62a4<\/h3>\nNMI\u5728\u81ea\u7136\u73af\u5883\u4e2d\u4e0d\u6613\u964d\u89e3\uff0c\u56e0\u6b64\u5728\u4f7f\u7528\u65f6\u9700\u8981\u91c7\u53d6\u9002\u5f53\u7684\u56de\u6536\u63aa\u65bd\uff0c\u4ee5\u51cf\u5c11\u5bf9\u751f\u6001\u7cfb\u7edf\u7684\u6f5c\u5728\u5371\u5bb3\u3002<\/p>\n \n\u5c55\u671b\u672a\u6765<\/h2>\n\u968f\u7740\u79d1\u5b66\u6280\u672f\u7684\u4e0d\u65ad\u8fdb\u6b65\uff0c1-\u7532\u57fa\u54aa\u5511\u7684\u5e94\u7528\u524d\u666f\u5c06\u66f4\u52a0\u5e7f\u9614\u3002\u7279\u522b\u662f\u5728\u7eff\u8272\u5316\u5b66\u548c\u53ef\u6301\u7eed\u53d1\u5c55\u9886\u57df\uff0cNMI\u6709\u671b\u53d1\u6325\u66f4\u5927\u7684\u4f5c\u7528\u3002\u4f8b\u5982\uff0c\u901a\u8fc7\u4f18\u5316\u5176\u5408\u6210\u5de5\u827a\uff0c\u53ef\u4ee5\u8fdb\u4e00\u6b65\u964d\u4f4e\u80fd\u8017\u548c\u6c61\u67d3\uff1b\u901a\u8fc7\u8bbe\u8ba1\u65b0\u578b\u529f\u80fd\u5316\u884d\u751f\u7269\uff0c\u53ef\u4ee5\u62d3\u5c55\u5176\u5728\u533b\u836f\u548c\u6750\u6599\u79d1\u5b66\u4e2d\u7684\u5e94\u7528\u8303\u56f4\u3002<\/p>\n \n\u7ed3\u8bed<\/h2>\n1-\u7532\u57fa\u54aa\u5511\uff08Lupragen NMI\uff09\u662f\u4e00\u6b3e\u6027\u80fd\u5353\u8d8a\u7684\u6709\u673a\u5316\u5408\u7269\uff0c\u5176\u72ec\u7279\u7684\u5316\u5b66\u6027\u8d28\u4f7f\u5176\u5728\u4f17\u591a\u9886\u57df\u4e2d\u4e0d\u53ef\u6216\u7f3a\u3002\u65e0\u8bba\u662f\u4f5c\u4e3a\u50ac\u5316\u5242\u3001\u91d1\u5c5e\u87af\u5408\u5242\u8fd8\u662f\u519c\u836f\u4e2d\u95f4\u4f53\uff0cNMI\u90fd\u80fd\u5c55\u73b0\u51fa\u5f3a\u5927\u7684\u5b9e\u529b\u3002\u7136\u800c\uff0c\u6211\u4eec\u4e5f\u5fc5\u987b\u6b63\u89c6\u5176\u6f5c\u5728\u7684\u5b89\u5168\u6027\u548c\u73af\u5883\u95ee\u9898\uff0c\u52aa\u529b\u5b9e\u73b0\u6280\u672f\u4e0e\u73af\u4fdd\u7684\u53cc\u8d62\u3002<\/p>\n \u5e0c\u671b\u672c\u6587\u80fd\u5e2e\u52a9\u4f60\u66f4\u597d\u5730\u4e86\u89e3\u8fd9\u4f4d\u201c\u5316\u5b66\u754c\u7684\u591a\u9762\u624b\u201d\u3002\u5982\u679c\u4f60\u5bf9NMI\u611f\u5174\u8da3\uff0c\u4e0d\u59a8\u4eb2\u81ea\u5c1d\u8bd5\u4e00\u4e0b\u5b83\u7684\u9b45\u529b\u5427\uff01😊<\/p>\n \n | | | | | | | | | | | | |
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